By appointment in my Webex Room.
Systems Biology and handling of parameterized models. Currently I focuse on the integration of data into multi-scale models with statistical methods and uncertainty tracking in the research unit QuaLiPerF.
- Sebastian, H., Jürgen, P., & Nicole, R. (2023). Bayesian estimation reveals that reproducible models in Systems Biology get more citations. Scientific Reports. https://doi.org/10.1038/s41598-023-29340-2
- Wagner, V., Höpfl, S., Klingel, V., Pop, M. C., & Radde, N. E. (2022). An inverse transformation algorithm to infer parameter distributions from population snapshot data. IFAC-PapersOnLine, 55(23), Article 23. https://doi.org/10.1016/j.ifacol.2023.01.020
- Albadry, M., Höpfl, S., Ehteshamzad, N., König, M., Böttcher, M., Neumann, J., Lupp, A., Dirsch, O., Radde, N., Christ, B., Christ, M., Schwen, L. O., Laue, H., Klopfleisch, R., & Dahmen, U. (2022). Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism. Scientific Reports, 12(1), Article 1. https://doi.org/10.1038/s41598-022-26483-6
- Christ, B., Collatz, M., Dahmen, U., Herrmann, K.-H., Höpfl, S., König, M., Lambers, L., Marz, M., Meyer, D., Radde, N., Reichenbach, J. R., Ricken, T., & Tautenhahn, H.-M. (2021). Hepatectomy-Induced Alterations in Hepatic Perfusion and Function - Toward Multi-Scale Computational Modeling for a Better Prediction of Post-hepatectomy Liver Function. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.733868
My focus is on the mathematical modeling of biological systems. The holistic view of systems biology in a field as complex as biology is what fascinates me the most. To gain knowledge from this context and thus develop drugs and help people is my motivation and passion. From my point of view, the best way to get this knowledge is to take a deeper look at the data we generate. Today we have great technologies to generate huge amounts of biological data. Analysing this data is fascinating to me and creating and validating models of this data also helps me to advance my understanding of systems biology.