This image shows Viviane Klingel

Viviane Klingel

M.Sc.

Research Assistant
Institute for Stochastics and Applications
Mathematical Modeling and Simulation of Cellular Systems
[Photo: Ludmilla Parsyak, © Fraunhofer IAO]

Contact

+49 711 685 60454
+49 711 685 67735

Website

Wankelstr. 5
70563 Stuttgart
Germany
Room: EG

Office Hours

With appointment in my Webex room.

Subject

I work in the field of Systems Biology where I currently focuse on the modeling of an epigenetic memory system.

Publications:
  1. Klingel, V., Graf, D., Weirich, S., Jeltsch, A., & Radde, N. E. (2022). Model-Based Design of a Synthetic Oscillator Based on an Epigenetic Methylation Memory System. ACS Synthetic Biology, 11(7), Article 7. https://doi.org/10.1021/acssynbio.2c00118
  2. Wagner, V., Höpfl, S., Klingel, V., Pop, M. C., & Radde, N. E. (2022). An inverse transformation algorithm to infer parameter distributions from population snapshot data. IFAC-PapersOnLine, 55(23), Article 23. https://doi.org/10.1016/j.ifacol.2023.01.020
  3. Graf, D., Laistner, L., Klingel, V., Radde, N. E., Weirich, S., & Jeltsch, A. (2022). Reversible switching and stability of the epigenetic memory system in bacteria. The FEBS Journal. https://doi.org/10.1111/febs.16690
  4. Adam, S., Bräcker, J., Klingel, V., Osteresch, B., Radde, N. E., Brockmeyer, J., Bashtrykov, P., & Jeltsch, A. (2022). Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns. Communications Biology, 5(1), Article 1. https://doi.org/10.1038/s42003-022-03033-4
  5. Klingel, V., Kirch, J., Ullrich, T., Weirich, S., Jeltsch, A., & Radde, N. E. (2021). Model-based robustness and bistability analysis for methylation-based, epigenetic memory systems. The FEBS Journal, 288(19), Article 19. https://doi.org/10.1111/febs.15838
  6. Broecker, J., Klingel, V., Ou, W.-L., Balo, A. R., Kissick, D. J., Ogata, C. M., Kuo, A., & Ernst, O. P. (2016). A Versatile System for High-Throughput In Situ X-ray Screening and Data Collection of Soluble and Membrane-Protein Crystals. Crystal Growth & Design, 16(11), Article 11. https://doi.org/10.1021/acs.cgd.6b00950
  7. Broecker, J., Morizumi, T., Ou, W.-L., Klingel, V., Kuo, A., Kissick, D. J., Ishchenko, A., Lee, M.-Y., Xu, S., Makarov, O., Cherezov, V., Ogata, C. M., & Ernst, O. P. (2018). High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions. Nature Protocols, 13(2), Article 2. https://doi.org/10.1038/nprot.2017.135
  • Teaching assistant for Grundlagen der Systembiologie (WS1920, WS2021, WS2122, WS 2223)
  • Teaching assistant for Stochastische Prozesse und Modellierung (SS19, SS20, SS21, SS22, SS23)
  • Teaching assistant for Dynamik biologischer Systeme (WS2021, WS2223)
  • Teaching assistant for Methoden in der Systembiologie (WS2122, WS2223)

since 02/2019

Research assistant at the Institute for Stochastics and Applications and at the Institute for Systems Theory and Automatic Control, University of Stuttgart, Germany.

04/2016-11/2018

Master studies in Technical Biology at the University of Stuttgart, Germany

  • Master thesis:
    "Feedback control of PKD activity and Golgi secretory function by the tumor suppressor DLC1"

04/2014-09/2017

Student assistant at the Institute of Biomaterials and Biomolecular Systems and Institute for Theoretical Chemistry.

04/2014-10/2015

International internship and Bachelor thesis at the University of Toronto, Canada.

10/2012-03/2016

Bachelor studies Technical Biology at the University of Stuttgart, Germany

  • Bachelor thesis:
    "Advances in in situ in meso X-ray Crystallography"

06/2012

Abitur at the Lise-Meitner Gymnasium, Königsbach-Stein, Germany

07/2009-05/2010

Exchange Year at Thatcher High School, Thatcher, Arizona, USA

Prizes:

The Best SimTech PhD Student Publication 2020/2021

Conferences:

BC2, Basel, 2021
SBMC, Heidelberg, 2022
FOSBE, Boston, 2022
ICSB, Berlin, 2022

Supervision of Student Theses:

1 Master Thesis
4 Bachelor Theses
1 Internship

As a representative of doctoral students member of:

  • University Senat since 2020
  • Faculty Council of Faculty 7 Dec. 2020 - Sept. 2022
  • Senate Committee for Structure since 2021
  • Senate Committee for Diversity and Equal Opportunities since 2021

Board member of the doctoral student representation DOKUS since 2020

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